There is a launch of norepinephrine from your descending inhibitory bulbospinal neurons that binds to alpha-two-receptors within the dorsal horn to reduce afferent discomfort transmission and produce analgesia. As a result, medication like clonidine that target alpha-2 receptors can impact the transmission of agony. : linked to, served by, https://www.proleviate.com/post/the-new-pain-killer-conolidine